The 3R's of Research; Refinement, Reduction and Replacement
Refining rodent physiological monitoring according to the New Guide
With the growth and expansion of mouse and rat transgenic models in recent years, the demand for surgically altered models mimicking human diseases is growing at an amazing rate. Surgical procedures are performed under anesthesia, and this has a profound effect on physiological systems and makes many protective mechanisms ineffective. Therefore it is critical to manage anesthetic depth so as to minimize adverse effects such as depression of respiration, and disruption of the cardiovascular system and thermoregulation. Physiological monitoring is an integral part of overall peri-operative care to ensure animal safety, and allow for control of physiological functions through the use of drugs, instrumentation, and the anesthetist's own senses. Additionally, the 8th Edition of the Guide for the Care and Use of Laboratory Animals incorporated a new subsection on intraoperative monitoring, which underlines the importance of physiological monitoring and stresses its importance during anesthesia.
Veterinary Bioscience Institute along with the Academy of Surgical Resesarch and Kent Scientific has developed a webinar for veterinary technicians, veterinarians, scientists, trainers and IACUC personnel adressing the hazards of not performing physiological monitoring, understand how anesthesia can be refined with the use of physiological monitoring. Attendees will also learn how to select appropriate, adequate and reliable equipment for physiological monitoring of rodents and learn how it can significantly increase the efficiency of anesthesia and prevent the over-anesthetizing of rodents.
Click 2014 Rodent physiological monitoring according to the New Guide to view this informative and exciting webinar.
Authors of this presentation also have writen an article entitled Improving Data Collection through Appropriate Rodent Peri-operative Monitoring and Care which yuo can access here.
Surgical Training Videos for iPrecio Minipump Implantation
Preclinical formulations and drug delivery are important to support early in vivo studies efficiently and productively. Implantable pumps have become a very convenient and cost effective met..
Refining Rodent Gavaging Technique
Oral gavage is a commonly performed method to administer materials orally to rodents. Instrumentation for this technique has been recently refined from a metal gavage needle to a flexible feeding tube..
Articles on Rodent Surgery Refinements and Other Topics
Please click on the title of article of interest to view it.
Introduction to Rodent Surgery:Tips for more successful procedures
Aseptic Technique in Rodent Surgery: Why Should I Pay Attention?